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Top Chief of Staff Jobs in San Francisco, CA
Automotive • Healthtech • Financial Services
Serve as a proactive strategic partner to the COO, driving prioritization, complex calendaring, executive preparation, board materials, and cross-functional project coordination to increase organizational clarity and execution.
Top Skills:
ExcelOutlookPowerPoint
Edtech • Enterprise Web • HR Tech • Software
As Chief of Staff at Handshake AI, you drive operations and strategy, translating ambiguous challenges into structured projects while championing AI-powered solutions.
Top Skills:
AIData ProductsFinancial ModelsMl
Artificial Intelligence • Insurance • Software
The Chief of Staff will work closely with the CEO on company execution, strategic planning, cross-functional leadership, and internal communications to drive outcomes and improve operational efficiency.
Artificial Intelligence • Software
The Chief of Staff to the CEO role requires strategic support for the CEO, managing decisions, prioritizing tasks, and ensuring company alignment.
Artificial Intelligence • Software
As Chief of Staff, drive strategic focus and execution for the CMO, managing operations and facilitating decision-making across global teams, with a strong emphasis on alignment and communication.
Top Skills:
Ai-Native Systems
Insurance
The Chief of Staff will enhance customer experience, optimize operations, manage initiatives, and bridge product and service areas while working closely with the CEO and COO.
Top Skills:
AnalyticsData Engineering
Artificial Intelligence • Software
Oversee operations and coordinate projects within engineering, acting as a liaison between management and engineers, providing technical support, and maintaining developer documentation.
Top Skills:
AWSAzureChakra UiGCPGitGoJavascript (Es6+)NextjsPythonReactRestful ApisTypescript
Artificial Intelligence • HR Tech • Productivity • Software
The Chief of Staff will work directly with the CEO to manage operations, nurture strategic pharmaceutical partnerships, and lead automation initiatives to enhance efficiency in drug production.
Top Skills:
N8NZapier
Artificial Intelligence • Healthtech
The Chief of Staff will enhance CEO's effectiveness by managing strategic initiatives, driving operations, supporting go-to-market efforts, and facilitating cross-functional collaboration.
Information Technology • Software
As Chief of Staff, you will partner with the CEO, drive strategic initiatives, manage executive communication, and support planning processes.
Top Skills:
SaaS
Healthtech
The Chief of Staff will partner with the CEO and senior leaders to drive strategic planning, oversee operations, coordinate leadership activities, and manage high-impact projects while fostering organizational culture and communications.
Top Skills:
AIData ScienceMachine Learning
Consumer Web • Mobile
The Chief of Staff for EPD acts as the operational and strategic partner to EPD leadership, managing organizational rhythms, priorities, and processes while ensuring effective communication and reporting across teams.
Top Skills:
Notion
New
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Artificial Intelligence • Software
As a Founder Associate at Arcade, you will collaborate directly with the CEO to address strategic challenges, improve operational systems, and contribute to growth initiatives with a hands-on approach.
Top Skills:
AirtableClayLinearNotionPythonSQLZapier
Artificial Intelligence • Machine Learning • Biotech
The Chief of Staff will support the CEO in operations and strategy, drive strategic decisions, facilitate leadership alignment, and manage cross-functional initiatives.
Top Skills:
AIData-Driven EnvironmentsDrug Discovery
Healthtech
The Chief of Staff to the CEO will act as a strategic advisor, manage mission-critical projects, and assist in scaling the company's reach by leveraging technical skills and industry knowledge.
Top Skills:
AIComputer Science
Professional Services
Serve as the Chairman's strategic partner and execution lead across ventures. Translate vision into plans, drive AI-enabled initiatives from prototype to deployment, implement systems and operating rhythms, manage high-priority projects, and represent the Chairman in key interactions while ensuring alignment, accountability, and operational velocity.
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Energy
The Chief of Staff will support the VP of Business Development & Finance, driving strategic initiatives, enhancing productivity, and ensuring effective decision-making across business functions.
Financial Services
The Chief of Staff will support the CEO by managing strategic planning, operational coordination, and internal communication. Responsibilities include run exec meetings, oversee initiatives, and prepare key investor updates.
Consumer Web
The Chief of Staff will work with the CCO to scale the commercial engine, lead strategic initiatives, drive performance, and ensure cross-functional alignment through effective communication and resource allocation.
Healthtech • Information Technology • Software
The Chief of Staff will work closely with the CEO in key business functions such as strategy, recruiting, and operations. The role requires exceptional interpersonal skills, strategic thinking, and a passion for health. Responsibilities include recruiting, investor relations, internal communications, brand management, and special projects, adapting to the needs of the company.
Artificial Intelligence • Fitness • Healthtech • Mobile • Software
The Chief of Staff will work closely with the CEO, ensuring effective communication, managing critical workflows, and driving project execution across teams. Responsibilities include advising the CEO, leading initiatives, and enhancing coordination between teams.
Machine Learning • Software
The Chief of Staff to the CTO will facilitate operational excellence, strategic partnerships, cross-functional alignment, and financial stewardship within the technology organization, ensuring execution aligns with the CTO's vision.
Top Skills:
Ai ToolsLlms
Software • Industrial
The Chief of Staff will oversee business operations, lead strategic projects, support customer deployments, and address challenges to achieve company goals.
Top Skills:
Financial ModelingRevenue Operations
Logistics • Software • Transportation
Partner with the CEO to run cross-functional initiatives: manage customer pilots and onboarding, incubate new products, own internal operations (finance, metrics, vendor management, board prep), and lead high-judgment strategic projects to drive outcomes and scale processes across the company.
Artificial Intelligence • Cloud • Software
The Chief of Staff will support the executive team by managing schedules, facilitating communication, and overseeing internal operations to enhance productivity.
Top San Francisco Companies Hiring Chiefs of Staff
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